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KMID : 1225720150070040312
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Allergy, Asthma & Immunology Research : AAIR
2015 Volume.7 No. 4 p.312 ~ p.320
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Seven Steps to the Diagnosis of NSAIDs Hypersensitivity: How to Apply a New Classification in Real Practice?
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Kowalski Marek L.
Makowska Joanna S.
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Abstract
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Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms and even life-threatening anaphylaxis. NSAID-induced hypersensitivity reactions may involve both immunological and non-immunological mechanisms and should be differentiated from type A adverse reactions. Clinical diagnosis and effective management of a hypersensitive patient cannot be achieved without identifying the underlying mechanism. In this review, we discuss the current classification of NSAID-induced adverse reactions and propose a practical diagnostic algorithm that involves 7 steps leading to the determination of the type of NSAID-induced hypersensitivity and allows for proper patient management
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KEYWORD
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Nonsteroidal anti-inflammatory drugs, NSAID-induced hypersensitivity, aspirin hypersensitivity, aspirin, drug allergy
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